Motif ID: DMAP1_NCOR{1,2}_SMARC.p2

Z-value: 2.229


Transcription factors associated with DMAP1_NCOR{1,2}_SMARC.p2:

Gene SymbolEntrez IDGene Name
DMAP1 55929 DNA methyltransferase 1 associated protein 1
NCOR1 9611 nuclear receptor co-repressor 1
NCOR2 9612 nuclear receptor co-repressor 2
SMARCA1 6594 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA5 8467 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCC2 6601 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SMARCA1chrX_-_128657453-0.511.6e-15Click!
SMARCA5chr4_+_1444345550.321.8e-06Click!
SMARCC2chr12_-_56583301-0.211.8e-03Click!
NCOR1chr17_-_159737600.203.4e-03Click!
NCOR2chr12_-_125052009-0.036.4e-01Click!


Activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2.

activity profile for motif DMAP1_NCOR{1,2}_SMARC.p2


Sorted Z-values histogram for motif DMAP1_NCOR{1,2}_SMARC.p2

Sorted Z-values for motif DMAP1_NCOR{1,2}_SMARC.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of DMAP1_NCOR{1,2}_SMARC.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_15114495 48.328 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_-_29641087 46.273 EVI2B
ecotropic viral integration site 2B
chr1_+_198608216 46.190 PTPRC
protein tyrosine phosphatase, receptor type, C
chr19_-_39826676 43.645 NM_004877
GMFG
glia maturation factor, gamma
chr19_-_39826625 41.101 GMFG
glia maturation factor, gamma
chr1_-_150738232 37.404 CTSS
cathepsin S
chr1_-_150738255 35.867 CTSS
cathepsin S
chr1_+_198608136 34.883 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr7_+_74188308 34.013 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr6_+_29691116 33.319 NM_001098478
NM_001098479
NM_018950
HLA-F


major histocompatibility complex, class I, F


chr18_-_51690988 32.364 MBD2
methyl-CpG binding domain protein 2
chr2_+_143886969 32.025 ARHGAP15
Rho GTPase activating protein 15
chr2_+_143886898 31.352 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr1_-_150738292 30.413 NM_001199739
NM_004079
CTSS

cathepsin S

chr5_-_169724734 27.402 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169724782 26.376 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_149792276 25.925 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_-_104905849 25.418 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr7_-_115670828 24.711 NM_001018058
NM_012252
TFEC

transcription factor EC

chr5_-_169724817 24.270 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr19_-_17516383 23.810 NM_004335
BST2
bone marrow stromal cell antigen 2
chr11_-_104972147 23.595 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chrX_+_37639246 23.233 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr22_+_23229959 22.721 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr15_+_89182038 22.500 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_32739711 22.486 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr1_+_167298280 21.835 NM_001198783
POU2F1
POU class 2 homeobox 1
chr17_-_80407601 21.790 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr13_-_46756326 21.147 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_29641094 20.951 NM_006495
EVI2B
ecotropic viral integration site 2B
chr7_-_115670774 20.477 TFEC
transcription factor EC
chr9_+_75766777 19.297 NM_000700
ANXA1
annexin A1
chr5_-_138725544 19.223 NM_016459
MZB1
marginal zone B and B1 cell-specific protein
chr6_-_24719286 18.693 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr12_+_25205180 18.360 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr11_+_5710926 18.125 TRIM22
tripartite motif containing 22
chr5_-_169724614 18.000 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr7_-_76829109 17.346 NM_006682
FGL2
fibrinogen-like 2
chr19_-_10679328 17.343 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chrX_+_37639306 17.084 CYBB
cytochrome b-245, beta polypeptide
chr17_-_34207308 17.036 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr6_+_26365397 16.785 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr16_-_4896197 16.464 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr1_+_948846 15.948 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr17_-_29641068 15.819 EVI2B
ecotropic viral integration site 2B
chr1_-_167487701 15.790 NM_000734
NM_198053
CD247

CD247 molecule

chr3_-_49851217 15.666 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_+_113162449 15.587 CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr1_+_15736387 15.332 NM_024329
EFHD2
EF-hand domain family, member D2
chr1_+_113162456 15.308 CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr1_+_198608244 15.167 PTPRC
protein tyrosine phosphatase, receptor type, C
chr16_-_21663962 15.036 NM_005849
IGSF6
immunoglobulin superfamily, member 6
chr1_+_113162074 14.936 NM_006135
CAPZA1
capping protein (actin filament) muscle Z-line, alpha 1
chr11_-_118213321 14.858 NM_000732
NM_001040651
CD3D

CD3d molecule, delta (CD3-TCR complex)

chr9_+_75766794 14.682 ANXA1
annexin A1
chr3_-_49142165 14.562 NM_005051
QARS
glutaminyl-tRNA synthetase
chr4_+_147096834 14.463 NM_007080
LSM6
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr8_+_26150731 14.444 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_32716839 14.426 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr19_-_47617008 14.400 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr12_-_10282680 14.357 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr15_+_80364902 14.328 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr5_-_149792370 14.016 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_+_15736422 13.868 EFHD2
EF-hand domain family, member D2
chr4_+_40198526 13.701 NM_004310
RHOH
ras homolog gene family, member H
chr11_+_63304272 13.513 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr11_+_5710816 13.237 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr3_-_50374875 13.174 NM_170713
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr1_+_158149736 13.064 NM_001766
CD1D
CD1d molecule
chr12_-_53601051 12.870 ITGB7
integrin, beta 7
chr6_-_32908583 12.854 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr1_+_174844655 12.377 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_25205488 12.247 LRMP
lymphoid-restricted membrane protein
chr14_-_23288912 11.990 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr16_-_21663908 11.846 IGSF6
immunoglobulin superfamily, member 6
chr3_+_151985828 11.596 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr5_+_156607847 11.290 NM_005546
ITK
IL2-inducible T-cell kinase
chrX_+_123480131 11.174 NM_001114937
NM_002351
SH2D1A

SH2 domain containing 1A

chr1_+_84630575 11.064 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr6_-_159239254 11.061 EZR
ezrin
chrX_+_123234462 10.997 STAG2
stromal antigen 2
chr1_+_79115476 10.895 NM_006417
IFI44
interferon-induced protein 44
chr7_-_77045706 10.851 NM_017439
PION
pigeon homolog (Drosophila)
chr3_-_50374795 10.828 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr11_-_10879365 10.710 NM_001143667
NM_021211
ZBED5

zinc finger, BED-type containing 5

chr6_+_138188352 10.688 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr2_+_172821874 10.450 HAT1
histone acetyltransferase 1
chr7_+_28452143 10.444 NM_182898
CREB5
cAMP responsive element binding protein 5
chr5_+_6746100 10.441 NM_001171806
PAPD7
PAP associated domain containing 7
chr1_+_159259503 10.243 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr6_-_159239198 10.199 EZR
ezrin
chr16_+_30773619 10.156 RNF40
ring finger protein 40
chr1_+_167298382 9.914 POU2F1
POU class 2 homeobox 1
chr10_-_123734708 9.886 NM_001167865
NM_017615
NSMCE4A

non-SMC element 4 homolog A (S. cerevisiae)

chr2_-_37899227 9.739 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr13_-_26789062 9.722 RNF6
ring finger protein (C3H2C3 type) 6
chr17_+_6659155 9.557 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr10_+_28878666 9.535 WAC
WW domain containing adaptor with coiled-coil
chr4_-_103748649 9.514 NM_181887
NM_181891
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr3_+_63953419 9.487 NM_001128149
ATXN7
ataxin 7
chr19_-_36233311 9.335 NM_024660
IGFLR1
IGF-like family receptor 1
chr19_+_10828725 9.295 NM_001005360
NM_001005361
NM_001005362
NM_001190716
NM_004945
DNM2




dynamin 2




chr3_-_50374749 9.280 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr17_+_7462064 9.251 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr19_-_50413063 9.015 NUP62
nucleoporin 62kDa
chr20_-_34243118 8.990 RBM12
RNA binding motif protein 12
chr6_-_159239269 8.987 NM_003379
EZR
ezrin
chr19_+_10828772 8.909 DNM2
dynamin 2
chr16_-_67970651 8.893 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr15_+_45003659 8.871 NM_004048
B2M
beta-2-microglobulin
chr1_-_151319717 8.850 NM_000449
NM_001025603
RFX5

regulatory factor X, 5 (influences HLA class II expression)

chr19_+_10828763 8.843 DNM2
dynamin 2
chr13_-_46756295 8.770 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_131573638 8.732 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr17_+_6659356 8.722 XAF1
XIAP associated factor 1
chr4_+_39063851 8.686 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr14_+_58711555 8.556 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_-_47841468 8.543 FAM117A
family with sequence similarity 117, member A
chr16_-_67970734 8.445 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr14_+_58711599 8.402 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr1_-_225616556 8.393 NM_194442
LBR
lamin B receptor
chr5_+_162930230 8.392 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr1_+_84630374 8.359 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr22_+_40322609 8.297 GRAP2
GRB2-related adaptor protein 2
chr14_+_58711457 8.249 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chrX_-_135863033 8.241 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr14_+_102276125 8.233 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr4_-_103748254 8.227 NM_181892
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_-_10679620 8.193 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr14_-_100841656 8.038 WARS
tryptophanyl-tRNA synthetase
chr20_-_52199635 7.998 NM_006526
ZNF217
zinc finger protein 217
chr14_-_100841793 7.737 WARS
tryptophanyl-tRNA synthetase
chr9_+_128510477 7.652 NM_001134778
PBX3
pre-B-cell leukemia homeobox 3
chr12_-_46357949 7.645


chr14_-_24683035 7.559 NM_014169
CHMP4A
charged multivesicular body protein 4A
chr6_+_26440699 7.558 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr6_-_32811773 7.536 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr17_-_34417386 7.500 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr2_+_103035148 7.448 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chrX_+_153770458 7.359 NM_001099856
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_+_149858466 7.321 NM_003517
HIST2H2AC
histone cluster 2, H2ac
chr1_-_33502470 7.313 AK2
adenylate kinase 2
chr5_-_142815076 7.144 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr3_+_111260925 7.060 NM_005816
NM_198196
CD96

CD96 molecule

chr19_-_48759141 7.011 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr1_+_41204509 6.985 NFYC
nuclear transcription factor Y, gamma
chr2_-_174828775 6.984 NM_001017371
SP3
Sp3 transcription factor
chr6_-_86351156 6.912 NM_001159675
NM_001159676
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr10_-_123734271 6.861 NSMCE4A
non-SMC element 4 homolog A (S. cerevisiae)
chr17_-_17184500 6.837 COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr1_-_207095198 6.822 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr1_-_8931634 6.742 NM_001201483
ENO1
enolase 1, (alpha)
chr12_-_49318663 6.634 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr19_+_17378148 6.629 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr7_-_99698993 6.625 MCM7
minichromosome maintenance complex component 7
chr12_-_49319211 6.604 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr13_-_103719195 6.534 NM_000452
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter family), member 2
chr1_-_33502484 6.512 NM_001199199
NM_001625
NM_013411
AK2


adenylate kinase 2


chr2_-_160472960 6.400 NM_013450
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr10_-_65028825 6.372 NM_004241
JMJD1C
jumonji domain containing 1C
chr20_-_23062786 6.369 CD93
CD93 molecule
chr14_+_102276279 6.360 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_91580713 6.244 C14orf159
chromosome 14 open reading frame 159
chrX_+_78200828 6.190 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr1_-_154580677 6.151 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr1_+_84630014 6.066 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr1_+_32757702 6.047 HDAC1
histone deacetylase 1
chr5_+_118691692 6.033 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr3_-_49851356 6.000 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr19_+_10828813 5.990 DNM2
dynamin 2
chr1_-_120935943 5.969 NM_001004340
NM_001017986
NM_001244910
FCGR1A
FCGR1B


Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)


chr7_-_99699030 5.896 MCM7
minichromosome maintenance complex component 7
chr11_-_47545539 5.853 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr6_+_26402464 5.838 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr19_+_17378264 5.830 BABAM1
BRISC and BRCA1 A complex member 1
chr17_+_39388714 5.804 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr10_-_14372807 5.783 NM_018027
FRMD4A
FERM domain containing 4A
chr1_+_43162386 5.779 YBX1
Y box binding protein 1
chr6_+_25963398 5.770 TRIM38
tripartite motif containing 38
chr11_-_8680382 5.749 NM_014818
TRIM66
tripartite motif containing 66
chr5_+_140602914 5.737 NM_018934
PCDHB14
protocadherin beta 14
chr6_+_25962978 5.699 NM_006355
TRIM38
tripartite motif containing 38
chr11_-_128391888 5.693 ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr2_+_182322265 5.678 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr13_-_47470967 5.666 NM_000621
NM_001165947
HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

chr19_+_10197023 5.649 C19orf66
chromosome 19 open reading frame 66
chr18_+_55019720 5.623 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr14_-_25103365 5.546 NM_004131
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr5_+_95997723 5.513 NM_001190442
CAST
calpastatin
chr21_-_33074101 5.512 SCAF4
SR-related CTD-associated factor 4
chr10_+_5772610 5.477 FAM208B
family with sequence similarity 208, member B
chr18_-_45457145 5.477 SMAD2
SMAD family member 2
chr3_+_121796695 5.469 NM_006889
NM_176892
CD86

CD86 molecule

chr17_+_65821625 5.432 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chr14_-_21899866 5.422 NM_001170629
CHD8
chromodomain helicase DNA binding protein 8
chr14_+_23340955 5.391 NM_014045
LRP10
low density lipoprotein receptor-related protein 10
chr14_-_75600111 5.376 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr19_+_10196972 5.355 C19orf66
chromosome 19 open reading frame 66
chr14_+_75988838 5.327 BATF
basic leucine zipper transcription factor, ATF-like
chr15_-_70390229 5.326 NM_001105192
NM_005078
NM_020908
TLE3


transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.53 6.16e-20 GO:0002376 immune system process
2.92 3.04e-17 GO:0006955 immune response
1.32 8.64e-12 GO:0065007 biological regulation
1.34 1.38e-11 GO:0050789 regulation of biological process
1.35 4.20e-11 GO:0050794 regulation of cellular process
1.75 7.27e-11 GO:0006950 response to stress
1.78 1.99e-10 GO:0090304 nucleic acid metabolic process
1.65 9.88e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.19 2.55e-09 GO:0009987 cellular process
1.46 3.80e-09 GO:0044260 cellular macromolecule metabolic process
1.63 1.11e-08 GO:0048518 positive regulation of biological process
2.42 1.19e-08 GO:0002682 regulation of immune system process
1.54 2.32e-08 GO:0060255 regulation of macromolecule metabolic process
1.64 1.06e-07 GO:0048522 positive regulation of cellular process
1.53 1.45e-07 GO:0034641 cellular nitrogen compound metabolic process
1.64 1.90e-07 GO:0048519 negative regulation of biological process
1.77 2.09e-07 GO:0016070 RNA metabolic process
1.97 3.12e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.38 3.54e-07 GO:0043170 macromolecule metabolic process
2.87 6.50e-07 GO:0044419 interspecies interaction between organisms
2.65 6.73e-07 GO:0050776 regulation of immune response
3.32 8.41e-07 GO:0045321 leukocyte activation
2.16 9.30e-07 GO:0006952 defense response
1.47 1.23e-06 GO:0031323 regulation of cellular metabolic process
1.44 1.39e-06 GO:0019222 regulation of metabolic process
1.49 1.58e-06 GO:0006807 nitrogen compound metabolic process
1.47 1.76e-06 GO:0080090 regulation of primary metabolic process
2.49 2.55e-06 GO:0001775 cell activation
2.74 4.47e-06 GO:0045087 innate immune response
1.85 6.04e-06 GO:0009893 positive regulation of metabolic process
1.88 6.51e-06 GO:0031325 positive regulation of cellular metabolic process
1.40 7.14e-06 GO:0051716 cellular response to stimulus
2.02 9.04e-06 GO:0051704 multi-organism process
1.61 1.04e-05 GO:0048523 negative regulation of cellular process
3.42 1.36e-05 GO:0046649 lymphocyte activation
1.96 1.44e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.42 1.94e-05 GO:0023052 signaling
1.64 4.03e-05 GO:0010467 gene expression
1.44 4.18e-05 GO:0007165 signal transduction
1.56 4.93e-05 GO:0051252 regulation of RNA metabolic process
1.62 6.23e-05 GO:0048583 regulation of response to stimulus
1.51 6.48e-05 GO:0010468 regulation of gene expression
1.28 7.85e-05 GO:0050896 response to stimulus
1.49 8.48e-05 GO:0051171 regulation of nitrogen compound metabolic process
4.02 9.77e-05 GO:0042110 T cell activation
1.49 1.47e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.27 1.61e-04 GO:0006974 response to DNA damage stimulus
2.24 1.91e-04 GO:0016071 mRNA metabolic process
5.28 1.96e-04 GO:0030217 T cell differentiation
2.74 2.16e-04 GO:0050778 positive regulation of immune response
1.83 2.45e-04 GO:0010941 regulation of cell death
2.71 2.83e-04 GO:0002520 immune system development
1.83 3.73e-04 GO:0042981 regulation of apoptosis
2.75 4.66e-04 GO:0048534 hemopoietic or lymphoid organ development
1.81 5.27e-04 GO:0043067 regulation of programmed cell death
4.14 5.72e-04 GO:0030098 lymphocyte differentiation
1.48 6.36e-04 GO:0010556 regulation of macromolecule biosynthetic process
2.30 7.16e-04 GO:0002684 positive regulation of immune system process
1.24 1.24e-03 GO:0044238 primary metabolic process
1.57 1.32e-03 GO:0007166 cell surface receptor linked signaling pathway
1.24 1.72e-03 GO:0044237 cellular metabolic process
1.46 2.66e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.92 2.72e-03 GO:0010557 positive regulation of macromolecule biosynthetic process
1.99 3.25e-03 GO:0006396 RNA processing
2.69 4.06e-03 GO:0030097 hemopoiesis
1.80 5.00e-03 GO:0009611 response to wounding
1.47 5.34e-03 GO:0006355 regulation of transcription, DNA-dependent
1.82 6.79e-03 GO:0031328 positive regulation of cellular biosynthetic process
3.67 6.85e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
1.41 7.24e-03 GO:0031326 regulation of cellular biosynthetic process
2.94 7.73e-03 GO:0002757 immune response-activating signal transduction
3.34 7.84e-03 GO:0002521 leukocyte differentiation
1.83 8.59e-03 GO:0048584 positive regulation of response to stimulus
1.41 8.78e-03 GO:0009889 regulation of biosynthetic process
2.03 9.46e-03 GO:0051253 negative regulation of RNA metabolic process
3.75 9.90e-03 GO:0050851 antigen receptor-mediated signaling pathway
2.66 1.14e-02 GO:0002253 activation of immune response
2.87 1.15e-02 GO:0002764 immune response-regulating signaling pathway
1.80 1.15e-02 GO:0033554 cellular response to stress
1.79 1.18e-02 GO:0009891 positive regulation of biosynthetic process
3.53 1.18e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.03 1.25e-02 GO:0045892 negative regulation of transcription, DNA-dependent
2.04 1.34e-02 GO:0080134 regulation of response to stress
4.07 1.45e-02 GO:0050852 T cell receptor signaling pathway
2.20 1.88e-02 GO:0006397 mRNA processing
1.88 1.96e-02 GO:0051254 positive regulation of RNA metabolic process
1.52 2.01e-02 GO:0009059 macromolecule biosynthetic process
1.82 2.03e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.79 2.25e-02 GO:0031399 regulation of protein modification process
1.69 2.27e-02 GO:0032268 regulation of cellular protein metabolic process
1.70 2.42e-02 GO:0009892 negative regulation of metabolic process
1.92 2.50e-02 GO:0010629 negative regulation of gene expression
1.73 2.53e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.90 2.66e-02 GO:0045893 positive regulation of transcription, DNA-dependent
2.73 2.66e-02 GO:0019221 cytokine-mediated signaling pathway
1.65 2.91e-02 GO:0051246 regulation of protein metabolic process
1.33 3.07e-02 GO:0016043 cellular component organization
1.51 3.35e-02 GO:0034645 cellular macromolecule biosynthetic process
1.72 3.40e-02 GO:0031324 negative regulation of cellular metabolic process
1.90 3.66e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.85 4.64e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.77 4.88e-02 GO:0051173 positive regulation of nitrogen compound metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 1.07e-10 GO:0005634 nucleus
1.87 8.57e-08 GO:0005654 nucleoplasm
1.16 1.05e-07 GO:0044424 intracellular part
1.45 3.87e-07 GO:0032991 macromolecular complex
1.62 4.44e-07 GO:0044428 nuclear part
1.15 6.71e-07 GO:0005622 intracellular
1.66 1.23e-06 GO:0031981 nuclear lumen
1.52 2.08e-05 GO:0031974 membrane-enclosed lumen
1.19 3.27e-05 GO:0043227 membrane-bounded organelle
1.17 3.64e-05 GO:0043226 organelle
1.51 3.72e-05 GO:0043233 organelle lumen
1.17 4.09e-05 GO:0043229 intracellular organelle
1.19 4.14e-05 GO:0043231 intracellular membrane-bounded organelle
1.53 7.33e-05 GO:0005829 cytosol
1.42 1.36e-04 GO:0043234 protein complex
1.47 4.19e-04 GO:0070013 intracellular organelle lumen
1.25 8.23e-04 GO:0044422 organelle part
1.24 1.35e-03 GO:0044446 intracellular organelle part
2.01 2.28e-03 GO:0030529 ribonucleoprotein complex
3.09 3.68e-03 GO:0043235 receptor complex
1.77 9.16e-03 GO:0044451 nucleoplasm part
1.05 2.14e-02 GO:0044464 cell part
1.05 2.18e-02 GO:0005623 cell
1.14 3.86e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.44 1.45e-21 GO:0005515 protein binding
1.18 2.95e-12 GO:0005488 binding
1.45 3.23e-06 GO:0003676 nucleic acid binding
1.53 1.22e-05 GO:0003677 DNA binding
1.88 2.44e-04 GO:0003723 RNA binding
6.00 5.95e-04 GO:0003823 antigen binding
2.44 1.49e-03 GO:0008134 transcription factor binding
1.90 1.50e-03 GO:0043565 sequence-specific DNA binding
1.67 5.02e-03 GO:0030528 transcription regulator activity
3.01 5.16e-03 GO:0003714 transcription corepressor activity
3.23 1.60e-02 GO:0019955 cytokine binding
5.04 2.61e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
2.13 4.29e-02 GO:0016563 transcription activator activity